Contraindications include: pregnancy and lactation, personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2 (MEN-2), history of pancreatitis, type 1 diabetes, severe gastrointestinal disease (including gastroparesis), and known hypersensitivity to GLP-1 analogues
The insulin concentration in the low- and high-glucose groups was measured using a Rat/Mouse Insulin ELISA kit (Merck KGaA, Darmstadt, Germany)
INTRODUCTION The physiological role of the gastrointestinal tract was traditionally thought to involve nutrient digestion and absorption, but it is now known to be the source of a plethora of peptide hormones involved in the regulation of metabolism and other body functions (Baggio & Drucker, 2007)
These studies clearly showed that the simultaneous activation of GIP and GLP1 receptors was anti-obesogenic and could be utilized for its therapeutic potential
Rigorously controlled additional studies are required to better determine the role of chronic inflammation in insulin resistance and glucose metabolism
preparing figures
